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incomparability    
非可比性; 不可比性

非可比性; 不可比性


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  • 核糖体合成和翻译后修饰肽究竟是什么？ - 知乎
    核糖体合成和翻译后修饰肽（Ribosomally synthesized and post-translationally modified peptides，简称RiPPs）是一大类天然产物，它们首先通过核糖体途径合成，如同普通的蛋白质一样，依据mRNA上的遗传密码进行。 然而，与典型的蛋白质不同，RiPPs在核糖体合成之后会经历一系列复杂的化学修饰过程，这些修饰可以极大地改变肽链的结构和功能特性。 这些翻译后修饰包括但不限于环化、氧化、磷酸化、甲基化、硫酯化等，这些变化能够让原本简单的线性肽链转变为具有高度多样性和生物活性的分子，比如抗生素、毒素、免疫调节剂等。
  • New developments in RiPP discovery, enzymology and engineering
    The review discusses the new classes of RiPPs that have been discovered, the advances in our understanding of the installation of both primary and secondary post-translational modifications, and the mechanisms by which the enzymes recognize the leader peptides in their substrates
  • A ribosomally synthesised and post-translationally modified peptide . . .
    Ribosomally synthesized and post-translationally modified peptides (RiPPs) are structurally complex natural products with diverse bioactivities
  • Recent advances in discovery and biosynthesis of ribosomally . . .
    This highlight focuses on the recent advances in the discovery and biosynthesis of bioactive lipopeptide natural products derived from ribosomally synthesized and post-translationally modified peptides
  • Discovery and engineering of ribosomally synthesized and post . . .
    This review provides a concise overview of the recent advances in the discovery of RiPP natural products, focusing on rational strategies such as bioactivity guided screening, enzyme or precursor-based genome mining, and biosynthetic engineering
  • Ribosomally Synthesized and Post-Translationally Modified Peptides . . .
    In this review, we focus on the versatile ThiF-like adenylyltransferase superfamily (TLATs), a group of enzymes essential for the biosynthesis of a diverse array of ribosomally synthesized and post-translationally modified peptides (RiPPs)
  • Recent Advances in Discovery, Bioengineering, and Bioactivity . . .
    Nevertheless, advances in genomics, bioinformatics, and chemical analytics have paved the way for ribosomally synthesized and post-translationally modified peptides (RiPPs), a structurally diverse group of natural products with a broad spectrum of biological activities as well as mode of mechanisms
  • Expanding molecular diversity of ribosomally synthesized and post . . .
    Ribosomally synthesized and post-translationally modified peptides (RiPPs) constitute a vast and diverse family of bioactive peptides These peptides, synthesized by ribosomes and subsequently modified by various tailoring enzymes, possess a wide chemical space
  • Discovery and engineering of ribosomally synthesized and post . . .
    This review provides a concise overview of the recent advances in the discovery of RiPP natural products, focusing on rational strategies such as bioactivity guided screening, enzyme or precursor-based genome mining, and biosynthetic engineering





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