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mythically    
ad. 神话地;虚构地

神话地;虚构地


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  • Glucagon-like peptide 1-based therapies for the treatment of . . . - UpToDate
    (See 'Cardiovascular effects' above and 'Microvascular outcomes' above and 'Monitoring' above ) Adverse effects – The side effects of GLP-1-based therapies are predominantly gastrointestinal, particularly nausea, vomiting, and diarrhea, and occur in 10 to 50 percent of patients
  • Glucagon-like peptide 1-based therapies for the treatment of . . . - UpToDate
    Adverse effects – The side effects of GLP-1 receptor agonist-based therapies are predominantly gastrointestinal, particularly nausea, vomiting, and diarrhea, and occur consistently in trials in 10 to 50 percent of patients
  • Dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment . . . - UpToDate
    INTRODUCTION Glucagon-like peptide 1 (GLP-1)-based therapies (eg, dipeptidyl peptidase 4 [DPP-4, DPP4] inhibitors, GLP-1 receptor agonists) affect glycemia through several mechanisms, including enhancement of glucose-dependent insulin secretion, slowed gastric emptying, and reduction of postprandial glucagon and food intake (table 1)
  • Options for type 2 diabetes treatment - UpToDate
    A1C: glycated hemoglobin; CVD: cardiovascular disease; DKA: diabetic ketoacidosis; DPP-4: dipeptidyl peptidase 4; eGFR: estimated glomerular filtration rate; GI: gastrointestinal; GIP: glucose-dependent insulinotropic polypeptide; GLP-1: glucagon-like peptide 1; HF: heart failure; MI: myocardial infarction; SGLT2: sodium-glucose cotransporter 2 * Initiation is contraindicated with eGFR <30 mL
  • Amylin analogs for the treatment of diabetes mellitus - UpToDate
    Abnormal regulation of these substances may contribute to the clinical presentation of diabetes The mechanism of action and therapeutic utility of amylin analogs will be reviewed here GLP-1-based therapies and overviews of pharmacologic therapy for type 1 and type 2 diabetes are presented separately
  • Glucagon-like peptide 1-based therapies for the treatment of . . . - UpToDate
    (See 'Cardiovascular effects' above and 'Microvascular outcomes' above and 'Monitoring' above ) Adverse effects – The side effects of GLP-1 receptor agonist-based therapies are predominantly gastrointestinal, particularly nausea, vomiting, and diarrhea, and occur consistently in trials in 10 to 50 percent of patients
  • Glucagon-like peptide 1 receptor agonists for the treatment . . . - UpToDate
    GLP-1 binds to a specific GLP-1 receptor, which is expressed in various tissues, including pancreatic beta cells, pancreatic ducts, gastric mucosa, kidney, lung, heart, skin, immune cells, and the hypothalamus [2,4] GLP-1 exerts its main effect by stimulating glucose-dependent insulin release from the pancreatic islets [2]
  • glp-1 - UpToDate
    GLP-1 also inhibits glucagon release and gastric emptying GLP-1 receptor agonists bind to the GLP-1 receptor and stimulate glucose-dependent insulin release from the pancreatic islets
  • Insulin therapy in type 2 diabetes mellitus - UpToDate
    In such patients, therapeutic options include adding an oral or injectable (glucagon-like peptide 1 [GLP-1]-based therapy or insulin) agent or switching to insulin monotherapy This topic will review the use of insulin therapy in nonpregnant patients with type 2 diabetes
  • Obesity in adults: Drug therapy - UpToDate
    The decision to initiate drug therapy in people with obesity should consider the risks and benefits of weight loss medications [1-5] The goals of drug therapy should be clear, along with an awareness that most medications require long-term use to maintain weight loss This topic will review drug treatments for patients with overweight and obesity





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